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PXD009525 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDual-function thermogelling polymers as effective endotamponade for retinal detachment repair and reassembly of vitreous-like body in-situ
DescriptionEndo-tamponade agents are crucial surgical adjuncts for vitreo-retinal surgery. Current clinical agents provide internal tamponade through buoyancy forces requiring the need for prolonged facing down post-operative positioning. Other disadvantages include temporary loss of vision, raised intra-ocular pressure, cataract formation and a need for an additional removal surgery. Therein lies an unmet clinical need to develop alternative biomaterials to overcome these key challenges. We describe a biocompatible and biodegradable thermogelling polymer which provides an internal tamponade effect through surface tension and viscosity. Furthermore, we demonstrate its surgical efficacy in the repair of retinal detachment in a non-human primate model. By three-month post-surgery, the thermogel undergoes biodegradation, and is replaced by a vitreous-like body, thereby mimicking the biophysical needs of the natural vitreous body. In summary, we demonstrate the potential superiority of our thermogel compared to current vitreous tamponade gold standards; and present a significant advancement in the use of biomaterials for vitreo-retinal surgery.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAsfa Alli Shaik
SpeciesList scientific name: Oryctolagus cuniculus (Rabbit); NCBI TaxID: 9986;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-04-17 08:38:34ID requested
12019-09-13 02:01:32announced
Publication List
Liu Z, Liow SS, Lai SL, Alli-Shaik A, Holder GE, Parikh BH, Krishnakumar S, Li Z, Tan MJ, Gunaratne J, Barathi VA, Hunziker W, Lakshminarayanan R, Tan CWT, Chee CK, Zhao P, Lingam G, Loh XJ, Su X, Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade. Nat Biomed Eng, 3(8):598-610(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Eye, vitreous, retinal detachment repair,thermogelling polymer, rabbit
Contact List
contact affiliationInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore
contact emailjayanthag@imcb.a-star.edu.sg
lab head
Asfa Alli Shaik
contact affiliationIMCB
contact emailasfaas@imcb.a-star.edu.sg
dataset submitter
Full Dataset Link List
Dataset FTP location
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