PXD009525-1

PXD009525 is an original dataset announced via ProteomeXchange.

Title	Dual-function thermogelling polymers as effective endotamponade for retinal detachment repair and reassembly of vitreous-like body in-situ
Description	Endo-tamponade agents are crucial surgical adjuncts for vitreo-retinal surgery. Current clinical agents provide internal tamponade through buoyancy forces requiring the need for prolonged facing down post-operative positioning. Other disadvantages include temporary loss of vision, raised intra-ocular pressure, cataract formation and a need for an additional removal surgery. Therein lies an unmet clinical need to develop alternative biomaterials to overcome these key challenges. We describe a biocompatible and biodegradable thermogelling polymer which provides an internal tamponade effect through surface tension and viscosity. Furthermore, we demonstrate its surgical efficacy in the repair of retinal detachment in a non-human primate model. By three-month post-surgery, the thermogel undergoes biodegradation, and is replaced by a vitreous-like body, thereby mimicking the biophysical needs of the natural vitreous body. In summary, we demonstrate the potential superiority of our thermogel compared to current vitreous tamponade gold standards; and present a significant advancement in the use of biomaterials for vitreo-retinal surgery.
HostingRepository	PRIDE
AnnounceDate	2019-09-13
AnnouncementXML	Submission_2019-09-13_02:01:31.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Asfa Alli Shaik
SpeciesList	scientific name: Oryctolagus cuniculus (Rabbit); NCBI TaxID: 9986;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-17 08:38:34	ID requested
⏵ 1	2019-09-13 02:01:32	announced

Liu Z, Liow SS, Lai SL, Alli-Shaik A, Holder GE, Parikh BH, Krishnakumar S, Li Z, Tan MJ, Gunaratne J, Barathi VA, Hunziker W, Lakshminarayanan R, Tan CWT, Chee CK, Zhao P, Lingam G, Loh XJ, Su X, Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade. Nat Biomed Eng, 3(8):598-610(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Eye, vitreous, retinal detachment repair,thermogelling polymer, rabbit

Jayantha GUNARATNE
contact affiliation	Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore
contact email	jayanthag@imcb.a-star.edu.sg
lab head
Asfa Alli Shaik
contact affiliation	IMCB
contact email	asfaas@imcb.a-star.edu.sg
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD009525
     1. Label: PRIDE project
     2. Name: Dual-function thermogelling polymers as effective endotamponade for retinal detachment repair and reassembly of vitreous-like body in-situ