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PXD009350-1

PXD009350 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics at large: Discovery and replication of plasma proteomic biomarkers in independent cohorts - Overweight and obese patients of the Weight Management Clinical program of The Ottawa Hospital
DescriptionHolistic human proteome maps are expected to complement comprehensive profile assessment of health and disease phenotypes. However, methodologies to analyze proteomes in human tissue or body fluid samples at relevant scale and performance are still limited in clinical research. Their deployment and demonstration in large enough human populations are even sparser. In the present study, we have characterized and compared the plasma proteomes of two large independent cohorts of obese and overweight individuals using shotgun MS-based proteomics. One cohort comes from a Canadian single-center clinical weight management program while the other one belongs to a multicenter pan-European weight loss study (i.e., the DiOGenes study for which MS proteomic data have been already deposited to the ProteomeXchange Consortium with the dataset identifier PXD005216). The MS proteomic data deposited herein corresponds to the cohort coming from the Weight Management Clinical program of The Ottawa Hospital.
HostingRepositoryPRIDE
AnnounceDate2018-11-23
AnnouncementXMLSubmission_2018-11-23_06:45:42.xml
DigitalObjectIdentifierhttp://dx.doi.org/10.6019/PXD009350
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterLoïc Dayon
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListAmmonia-loss; Deamidated; TMT6plex; Dehydrated; Oxidation; Acetyl; Carbamidomethyl
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-03-28 01:15:49ID requested
12018-11-23 06:45:44announced
Publication List
Cominetti O, Núñez Galindo A, Corthésy J, Valsesia A, Irincheeva I, Kussmann M, Saris WHM, Astrup A, McPherson R, Harper ME, Dent R, Hager J, Dayon L, Obesity shows preserved plasma proteome in large independent clinical cohorts. Sci Rep, 8(1):16981(2018) [pubmed]
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: Biomarker, Mass spectrometry, Plasma association map, Proteomics, Obesity, Overweight, Replication
Contact List
Loïc Dayon
contact affiliationProteomics Team, Nestlé Institute of Health Sciences, Lausanne, Switzerland
contact emailloic.dayon@rd.nestle.com
lab head
Loïc Dayon
contact affiliationNestlé Institute of Health Sciences SA
contact emailloic.dayon@rd.nestle.com
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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