PXD009338

PXD009338 is an original dataset announced via ProteomeXchange.

Title	Protein Interactions of 7 MLL-fusion Proteins
Description	MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL protein. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain poorly understood. We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins: MLL-AF1p, MLL-AF4, MLL-AF9, MLL-CBP, MLL-EEN, MLL-ENL and MLL-GAS7.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:44:50.233.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexey Stukalov
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-27 00:04:24	ID requested
1	2018-05-25 00:57:12	announced
⏵ 2	2024-10-22 04:44:52	announced	2024-10-22: Updated project metadata.

Skucha A, Ebner J, Schm, ö, llerl J, Roth M, Eder T, C, é, sar-Razquin A, Stukalov A, Vittori S, Muhar M, Lu B, Aichinger M, Jude J, M, ü, ller AC, Gy, ő, rffy B, Vakoc CR, Valent P, Bennett KL, Zuber J, Superti-Furga G, Grebien F, MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nat Commun, 9(1):1983(2018) [pubmed]

10.1038/s41467-018-04329-y;

curator keyword: Biomedical

submitter keyword: MLL-fusion, leukemia,human

Florian Grebien
contact affiliation	Ludwig Boltzmann Institute Cancer Research, Vienna, Austria
contact email	florian.grebien@lbicr.lbg.ac.at
lab head
Alexey Stukalov
contact affiliation	Technical University of Munich
contact email	alexey.stukalov@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD009338

PRIDE project URI

• PRIDE
  1. PXD009338
     1. Label: PRIDE project
     2. Name: Protein Interactions of 7 MLL-fusion Proteins