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PXD009338 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProtein Interactions of 7 MLL-fusion Proteins
DescriptionMLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL protein. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain poorly understood. We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins: MLL-AF1p, MLL-AF4, MLL-AF9, MLL-CBP, MLL-EEN, MLL-ENL and MLL-GAS7.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAlexey Stukalov
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-03-27 00:04:24ID requested
12018-05-25 00:57:12announced
Publication List
Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César-Razquin A, Stukalov A, Vittori S, Muhar M, Lu B, Aichinger M, Jude J, Müller AC, Győrffy B, Vakoc CR, Valent P, Bennett KL, Zuber J, Superti-Furga G, Grebien F, MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nat Commun, 9(1):1983(2018) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: human, MLL-fusion, leukemia
Contact List
Florian Grebien
contact affiliationLudwig Boltzmann Institute Cancer Research, Vienna, Austria
contact emailflorian.grebien@lbicr.lbg.ac.at
lab head
Alexey Stukalov
contact affiliationTechnical University of Munich
contact emailalexey.stukalov@tum.de
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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