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PXD008921-1

PXD008921 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA new tool to reveal bacterial signaling mechanisms in antibiotic treatment and resistance
DescriptionAntimicrobial resistance is widespread across the globe. Here we presented a dynamic view of protein phosphoregulations during resistance development. Specific phosphorylation motifs and highly conserved phosphorylated residues on transcription factors were identified involving in regulating resistance for the first time implying the extent of phosphorylation regulation is far more important than we thought. Much effort need to be done in understanding the contribution of each signaling pathway to the development of resistance. Therefore, the dataset presented here could be a valuable resource for future works to decipher signaling mechanisms involved in AMR.
HostingRepositoryjPOST
AnnounceDate2018-09-21
AnnouncementXMLSubmission_2018-09-20_19:47:19.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMiao-Hsia Lin
SpeciesList scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationListS-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide; O4'-phospho-L-tyrosine; O-phospho-L-serine; O-phospho-L-threonine; phosphorylated L-histidine; L-aspartic 4-phosphoric anhydride
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-02-09 12:37:57ID requested
12018-09-20 19:47:20announced
22021-02-04 17:04:38announced2021-02-04: Updated FTP location.
32022-09-18 02:49:34announced2022-09-18: Updated FTP location.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: antimicrobial resistance, phosphoproteomics, colistin, ciporlfoxacin
Contact List
Simone Lemeer
lab head
Miao-Hsia Lin
contact affiliationInstitute of Chemistry, Academia Sinica
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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