PXD008797 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Exoproteome analysis of Staphylococcus aureus clinical isolates belonging to different clonal complexes (C22, CC8 and CC398) |
Description | Studies on S. aureus sub-populations revealed that genomes are well conserved between isolates from the same lineages despite geographic, temporal and selective diversity. However, variation of hundreds of genes can occur between isolates from different lineages and these genes could be involved in interaction with host components. In this study, we aimed to investigate the diversity of secreted virulence factors in human and zoonotic S. aureus isolates from different clonal complexes. We focused on the S. aureus clonal complexes (CC) 8 and CC22 as dominant human lineages, and CC398 as dominant livestock-associated MRSA (LA-MRSA) which is disseminating rapidly. To study the diversity of secreted virulence factors, we compared their extracellular proteomes using label-free LC-MS/MS analysis. A common protein database was created based on DNA sequencing data and PAN genome IDs. |
HostingRepository | PRIDE |
AnnounceDate | 2018-09-11 |
AnnouncementXML | Submission_2018-09-11_02:27:47.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tobias Busche |
SpeciesList | scientific name: Staphylococcus aureus; NCBI TaxID: 1280; |
ModificationList | iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-01-30 05:54:57 | ID requested | |
⏵ 1 | 2018-09-11 02:27:48 | announced | |
2 | 2018-09-17 00:15:12 | announced | Updated publication reference for PubMed record(s): 30201737. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological |
submitter keyword: Staphylococcus aureus, clonal complex, virulence factors, exoproteome, secretome |
Contact List
Haike Antelmann |
contact affiliation | Freie Universität Berlin Institut für Biologie-Mikrobiologie Königin-Luise-Straße 12-16 14195 Berlin Germany ( lab head ) |
contact email | haike.antelmann@fu-berlin.de |
lab head | |
Tobias Busche |
contact affiliation | Freie Universität Berlin, Institute for Biology-Microbiology, D-14195 Berlin, Germany |
contact email | tbusche@cebitec.uni-bielefeld.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD008797
- Label: PRIDE project
- Name: Exoproteome analysis of Staphylococcus aureus clinical isolates belonging to different clonal complexes (C22, CC8 and CC398)