PXD008771

PXD008771 is an original dataset announced via ProteomeXchange.

Title	A proteomics landscape of circadian clock in mouse liver
Description	As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a TF DNA-binding activity centered multi-dimensional proteomics landscape, including DNA-binding activity of TFs, the phosphorylation pattern, ubiquitylation pattern, the nuclear sub-proteome, the whole proteome as well as the transcriptome, to portrait the hierarchical circadian clock network of mouse liver. The TF DNA-binding activity indicates diurnal oscillation in four major pathways, immune response, glucose metabolism, fatty acid metabolism, and the cell cycle. We also isolated the mouse liver Kupffer cells and measured their proteomes in the circadian clock to reveal cell type resolved circadian clock. These are the most comprehensive datasets for circadian clock in the mouse liver and provided the richest data resource for the understanding of mouse liver physiology around the circadian clock.
HostingRepository	iProX
AnnounceDate	2018-06-25
AnnouncementXML	Submission_2018-09-16_01:41:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lei Song
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-27 06:09:17	ID requested
1	2018-01-27 06:09:42	announced
2	2018-09-16 01:13:07	announced	Update publication information
⏵ 3	2018-09-16 01:41:19	announced	Update publication information

Wang Y, Song L, Liu M, Ge R, Zhou Q, Liu W, Li R, Qie J, Zhen B, Wang Y, He F, Qin J, Ding C, A proteomics landscape of circadian clock in mouse liver. Nat Commun, 9(1):1553(2018) [pubmed]

submitter keyword: proteomics , circadian clock, mouse liver

Jun Qin
contact affiliation	State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing 102206, China;
contact email	jqin@bcm.edu
lab head
Lei Song
contact affiliation	Beijing Proteome Research Center, National Center for Protein Sciences, Beijing
contact email	duohu@163.com
dataset submitter

iProX dataset URI