PXD008448

PXD008448 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection
Description	A Toxoplasma gondii infection during pregnancy can result in spontaneous abortion, preterm labor, or congenital fetal defects. The decidual immune system plays a critical role in regulating the immune micro-environment and in the induction of immune tolerance. To better understand the factors that mediate the decidual immune response associated with the T. gondii infection, a large-scale study employing TMT proteomics was conducted to characterize the differential decidual immune proteomes from infected and uninfected human decidual immune cells samples. The decidual immune cells from 105 human voluntary abortion tissues were purified, and of the 5510 unique proteins identified, 181 proteins were found to be differentially abundant (>1.2-fold cutoff, P＜0.05) in the T. gondii-infected decidual immune cells. 11 proteins of 181 differentially expressed proteins associated with trophoblast invasion, placental development, intrauterine fetal growth, and immune tolerance were verified using a quantitative real-time polymerase chain reaction and western blotting. This systematic research identified a broad range of immune factors in human decidual immune cells, shedding a new insight into the decidual immune molecular mechanism for abnormal pregnancy outcomes associated with T. gondii infection.
HostingRepository	PRIDE
AnnounceDate	2018-07-27
AnnouncementXML	Submission_2018-07-27_08:28:23.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rachel Green
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-14 01:39:48	ID requested
⏵ 1	2018-07-27 08:28:24	announced

Zhang D, Sun X, Ren L, Yang C, Liu X, Zhang H, Jiang Y, Hu X, Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection. J Proteomics, 186():28-37(2018) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Decidual immune cells

infection

Proteomics

TMT

Toxoplasma gondii

Xuemei Hu
contact affiliation	Department of Medicine & Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, P. R. China, 264003
contact email	xue-mei-hu@163.com
lab head
Rachel Green
contact affiliation	PTM Biolabs Inc.
contact email	xuan_mao@ptm-biolab.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD008448

PRIDE project URI

• PRIDE
  1. PXD008448
     1. Label: PRIDE project
     2. Name: Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection