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PXD008390-1

PXD008390 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGalectins control mTOR in response to endomembrane damage
DescriptionThe Ser/Thr protein kinase mTOR controls metabolic pathways, including the catabolic process of autophagy. Autophagy plays additional, catabolism-independent roles in homeostasis of cytoplasmic endomembranes and whole organelles. How signals from endomembrane damage are transmitted to mTOR to orchestrate autophagic responses is not known. Here we show that mTOR is inhibited by lysosomal damage. Lysosomal damage, recognized by galectins, leads to association of Gal8 with mTOR apparatus on the lysosome. Gal8 inhibits mTOR activity through its Ragulator-Rag signaling machinery. Thus, a novel galectin-based signal-transduction apparatus, termed here GALTOR, controls mTOR in response to lysosomal damage.
HostingRepositoryMassIVE
AnnounceDate2018-03-27
AnnouncementXMLSubmission_2018-03-27_15:45:08.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBrett Phinney
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListDeamidated; Oxidation
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-12-07 09:49:12ID requested
12018-03-27 15:45:08announced
Publication List
no publication
Keyword List
submitter keyword: mTOR, Galectins, endomembrane
Contact List
Vojo Deretic
contact affiliation University of New Mexico Health Sciences Center
contact emailvderetic@salud.unm.edu
lab head
Brett Phinney
contact affiliationUC Davis
contact emailbrettsp@ucdavis.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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