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DataSet Summary

  • HostingRepository: MassIVE
  • AnnounceDate: 2018-02-09
  • AnnouncementXML: Submission_2018-02-09_17:34:38.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Non peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Birgit Schilling
  • Title: Refinement of synapses without postsynaptic activity: Role for a 4E-BP dependent mechanism
  • Description: Refinement of synaptic connections during development requires both the elimination of some inputs and the strengthening of others. It is well accepted that this competitive process takes place throughout the nervous system and relies on synaptic activity. However, the mechanisms that link activity to refinement remain largely unresolved. Here we demonstrate that refinement of preganglionic axons in sympathetic ganglia, a process that depends unequivocally on synaptic activity, involves eukaryotic initiation factor 4E binding protein (4E-BP), a protein that regulates cap-dependent translation. In mice lacking the 3 nicotinic receptor subunit, silent synapses between preganglionic axons and postsynaptic nicotinic neurons do not refine unless synaptic activity is restored, or surprisingly, when 4E-BP is absent. Our findings demonstrate that synapses can refine in the absence of synaptic activity during development and identify 4E-BP as a critical player in this process.
  • SpeciesList: scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
  • ModificationList: unknown modification: NA
  • Instrument: TripleTOF 6600

Dataset History

VersionDatetimeStatusChangeLog Entry
02017-07-26 19:51:35ID requested
12018-02-09 17:34:38announced

Publication List

  1. no publication

Keyword List

  1. submitter keyword: postsynaptic density, protein expression, data-independent acquisition

Contact List

    Birgit Schilling
    • contact affiliation: Buck Institute
    • contact email: bschilling@buckinstitute.org
    • lab head:
    Birgit Schilling
    • contact affiliation: Buck Institute
    • contact email: bschilling@buckinstitute.org
    • dataset submitter:

Full Dataset Link List

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  2. Dataset FTP location

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