PXD006711 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | SNAIL is a key regulator of rhabdomyosarcoma progression and myogenic differentiation |
Description | Rhabdomyosarcoma (RMS) is a frequent non-epithelial tumor of soft tissue that originates from a myogenic differentiation defect. Expression of SNAIL transcription factor is elevated in the alveolar subtype of RMS, characterized by a low myogenic differentiation status and high aggressiveness. SNAIL affects RMS metastasis by reorganization of actin cytoskeleton, regulation of ezrin expression and chemotaxis to HGF and SDF-1. The differentiation of human RMS diminishes SNAIL level. SNAIL silencing completely abolishes the growth of human RMS xenotransplants. SNAIL inhibits myogenic differentiation of RMS by binding to the MYF5 promoter, suppressing its expression, displacing MYOD from canonical to alternative E-box sequences and regulating myomiRs expression. SNAIL silencing allows the re-expression of MYF5 and canonical MYOD binding, promoting RMS cell myogenic differentiation. These novel results open potential avenues for the development of innovative therapeutic strategies based on SNAIL silencing. |
HostingRepository | PRIDE |
AnnounceDate | 2020-07-14 |
AnnouncementXML | Submission_2020-07-13_22:49:43.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD006711 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Urszula Jankowska |
SpeciesList | scientific name: Homo sapiens (human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | micrOTOF-Q II |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-06-14 03:00:17 | ID requested | |
⏵ 1 | 2020-07-13 22:49:43 | announced | |
2 | 2020-07-18 18:36:54 | announced | 2020-07-19: Updated publication reference for PubMed record(s): 32664538. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: SNAIL (SNAI1), rhabdomyosarcoma (RMS), myogenic differentiation, MYOD, MYF5, metastasis, myomiRs |
Contact List
Sylwia Kędracka-Krok |
contact affiliation | Department of Physical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland |
contact email | sylwi.kedracka-krok@uj.edu.pl |
lab head | |
Urszula Jankowska |
contact affiliation | Jagiellonian University |
contact email | urszula.jankowska@uj.edu.pl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD006711
- Label: PRIDE project
- Name: SNAIL is a key regulator of rhabdomyosarcoma progression and myogenic differentiation