PXD006382-1

PXD006382 is an original dataset announced via ProteomeXchange.

Title	Subregion-specific proteomic signature in the hippocampus for memory formation in adult mice
Description	The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has exquisite differences in anatomical organization and cellular composition, and hippocampal sub-regions have different properties and functional roles. Areas CA1 and CA3 in particular, are key sub-regions for learning and memory formation that fulfill complementary but specific functions. The molecular basis for such specific properties and the link to learning and memory remain unknown. Here using a SWATH-MS proteomic approach and bioinformatic tools, we identify a selective proteomic signature in area CA1 and CA3, and reveal their specific dynamics during memory formation. We show that 30% of all quantifiable proteins are differentially expressed in area CA1 and CA3 at baseline, and that each proteome responds differently during the formation of memory for object or object location. Using clustering and cross-correlational analyses, we outline specific temporal proteomic profiles and an increased correlation between both forms of memory within area CA1, but not within area CA3. These results provide new insight into a proteomic basis for hippocampal sub-region molecular and functional specificity.
HostingRepository	PRIDE
AnnounceDate	2018-03-28
AnnouncementXML	Submission_2018-03-28_02:42:39.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lukas von Ziegler
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2017-04-25 08:12:46	ID requested
⏵ 1	2018-03-28 02:42:40	announced

von Ziegler LM, Selevsek N, Tweedie-Cullen RY, Kremer E, Mansuy IM, Subregion-Specific Proteomic Signature in the Hippocampus for Recognition Processes in Adult Mice. Cell Rep, 22(12):3362-3374(2018) [pubmed]

curator keyword: Biological

submitter keyword: SWATH-MS LC-MS/MS hippocampus ca1 ca3 mouse memory recognition

Prof. Isabelle M. Mansuy
contact affiliation	Laboratory of Neuroepigenetics, University of Zürich/Swiss Federal Institute of Technology, Brain Research Institute, Neuroscience Center Zürich, Winterthurerstrasse 190, Zürich CH-8057, Switzerland
contact email	mansuy@hifo.uzh.ch
lab head
Lukas von Ziegler
contact affiliation	Swiss Federal Institute of Technology
contact email	vonziegler@hifo.uzh.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/03/PXD006382

PRIDE project URI

• PRIDE
  1. PXD006382
     1. Label: PRIDE project
     2. Name: Subregion-specific proteomic signature in the hippocampus for memory formation in adult mice