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PXD006382 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSubregion-specific proteomic signature in the hippocampus for memory formation in adult mice
DescriptionThe hippocampal formation is a brain structure essential for higher-order cognitive functions. It has exquisite differences in anatomical organization and cellular composition, and hippocampal sub-regions have different properties and functional roles. Areas CA1 and CA3 in particular, are key sub-regions for learning and memory formation that fulfill complementary but specific functions. The molecular basis for such specific properties and the link to learning and memory remain unknown. Here using a SWATH-MS proteomic approach and bioinformatic tools, we identify a selective proteomic signature in area CA1 and CA3, and reveal their specific dynamics during memory formation. We show that 30% of all quantifiable proteins are differentially expressed in area CA1 and CA3 at baseline, and that each proteome responds differently during the formation of memory for object or object location. Using clustering and cross-correlational analyses, we outline specific temporal proteomic profiles and an increased correlation between both forms of memory within area CA1, but not within area CA3. These results provide new insight into a proteomic basis for hippocampal sub-region molecular and functional specificity.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLukas von Ziegler
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-04-25 08:12:46ID requested
12018-03-28 02:42:40announced
Publication List
von Ziegler LM, Selevsek N, Tweedie-Cullen RY, Kremer E, Mansuy IM, Subregion-Specific Proteomic Signature in the Hippocampus for Recognition Processes in Adult Mice. Cell Rep, 22(12):3362-3374(2018) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: SWATH-MS LC-MS/MS hippocampus ca1 ca3 mouse memory recognition
Contact List
Prof. Isabelle M. Mansuy
contact affiliationLaboratory of Neuroepigenetics, University of Zürich/Swiss Federal Institute of Technology, Brain Research Institute, Neuroscience Center Zürich, Winterthurerstrasse 190, Zürich CH-8057, Switzerland
contact emailmansuy@hifo.uzh.ch
lab head
Lukas von Ziegler
contact affiliationSwiss Federal Institute of Technology
contact emailvonziegler@hifo.uzh.ch
dataset submitter
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