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PXD006089 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAhR interactome in early embryonic development
DescriptionThe transcriptional program of early embryonic development is tightly regulated by a set of well-defined transcription factors that suppress premature expression of differentiation genes and sustain the pluripotent identity. It is generally accepted that this program can be perturbed by environmental factors such as chemical pollutants, however the precise molecular mechanisms remain unknown. The Aryl Hydrocarbon Receptor (AHR) is a widely expressed nuclear receptor that senses environmental stimuli and modulates target gene expression. Here, we show that ectopic activation of AHR during early differentiation disrupts the differentiation program via the chromatin remodeling complex NuRD. The activated AHR/NuRD complex altered the expression of differentiation-specific genes that control the first two developmental decisions without affecting the pluripotency program. These findings identify a novel mechanism that allows environmental stimuli to disrupt embryonic development through AHR signaling.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJames Wright
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList2-pyrrolidone-5-carboxylic acid (Glu); monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentLTQ FT
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-03-14 03:56:14ID requested
12018-02-26 10:29:59announced
Publication List
Gialitakis M, Tolaini M, Li Y, Pardo M, Yu L, Toribio A, Choudhary JS, Niakan K, Papayannopoulos V, Stockinger B, Activation of the Aryl Hydrocarbon Receptor Interferes with Early Embryonic Development. Stem Cell Reports, 9(5):1377-1386(2017) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: AHR, interactome, NuRD, embryonic development, environmental pollutants
Contact List
Jyoti Choudhary
contact affiliationWellcome Trust Sanger Institute
contact emailjc4@sanger.ac.uk
lab head
James Wright
contact affiliationProteomic Mass Spectrometry, Wellcome Trust Sanger Institute
contact emailjw13@sanger.ac.uk
dataset submitter
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Dataset FTP location
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