PXD005035-1

PXD005035 is an original dataset announced via ProteomeXchange.

Title	Mouse muscle LC-MSMS upon weightlessness
Description	Upon weightlessness and microgravity, deleterious effects on the neurosensory and neurovestibular systems, haematological changes, and deconditioning of musculoskeletal, cardiovascular and cardiopulmonary functions have been reported. In particular, loss of muscle mass and strength are triggered by weightlessness in humans during space flights, what is similarly observed as a result of physical inactivity conditions and ageing on Earth. However, skeletal muscle tissue is of paramount importance for health maintenance (e.g. being essential to locomotion, heat production, and metabolism). To better prevent or eventually treat microgravity-induced muscle atrophy, its underlying mechanisms have first to be characterized in details. Using cutting-edge quantitative proteomics, the aim of the present study was therefore to get an in depth view of the molecular regulations triggered by space conditions in skeletal muscles of mice during the 30-day flight of the BION-M1 biosatellite. As muscles differing in their fiber type composition appear to respond differently to microgravity (see above), we characterized here the differential response of the soleus, extensor digitorum longus and vastus lateralis muscles.
HostingRepository	PRIDE
AnnounceDate	2017-06-14
AnnouncementXML	Submission_2017-06-14_00:05:19.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fabrice BERTILE
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-09-26 07:18:33	ID requested
⏵ 1	2017-06-14 00:05:20	announced

Tascher G, Brioche T, Maes P, Chopard A, O'Gorman D, Gauquelin-Koch G, Blanc S, Bertile F, Proteome-wide Adaptations of Mouse Skeletal Muscles during a Full Month in Space. J Proteome Res, 16(7):2623-2638(2017) [pubmed]

curator keyword: Biological

submitter keyword: Mice, muscles, spaceflight, LC-MSMS

Sarah Cianférani
contact affiliation	Laboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Strasbourg, France
contact email	sarah.cianferani@unistra.fr
lab head
Fabrice BERTILE
contact affiliation	CNRS
contact email	fbertile@unistra.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/06/PXD005035

PRIDE project URI

• PRIDE
  1. PXD005035
     1. Label: PRIDE project
     2. Name: Mouse muscle LC-MSMS upon weightlessness