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PXD005035

PXD005035 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMouse muscle LC-MSMS upon weightlessness
DescriptionUpon weightlessness and microgravity, deleterious effects on the neurosensory and neurovestibular systems, haematological changes, and deconditioning of musculoskeletal, cardiovascular and cardiopulmonary functions have been reported. In particular, loss of muscle mass and strength are triggered by weightlessness in humans during space flights, what is similarly observed as a result of physical inactivity conditions and ageing on Earth. However, skeletal muscle tissue is of paramount importance for health maintenance (e.g. being essential to locomotion, heat production, and metabolism). To better prevent or eventually treat microgravity-induced muscle atrophy, its underlying mechanisms have first to be characterized in details. Using cutting-edge quantitative proteomics, the aim of the present study was therefore to get an in depth view of the molecular regulations triggered by space conditions in skeletal muscles of mice during the 30-day flight of the BION-M1 biosatellite. As muscles differing in their fiber type composition appear to respond differently to microgravity (see above), we characterized here the differential response of the soleus, extensor digitorum longus and vastus lateralis muscles.
HostingRepositoryPRIDE
AnnounceDate2017-06-14
AnnouncementXMLSubmission_2017-06-14_00:05:19.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFabrice BERTILE
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-09-26 07:18:33ID requested
12017-06-14 00:05:20announced
Publication List
Tascher G, Brioche T, Maes P, Chopard A, O'Gorman D, Gauquelin-Koch G, Blanc S, Bertile F, Proteome-wide Adaptations of Mouse Skeletal Muscles during a Full Month in Space. J Proteome Res, 16(7):2623-2638(2017) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Mice, muscles, spaceflight, LC-MSMS
Contact List
Sarah Cianférani
contact affiliationLaboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Strasbourg, France
contact emailsarah.cianferani@unistra.fr
lab head
Fabrice BERTILE
contact affiliationCNRS
contact emailfbertile@unistra.fr
dataset submitter
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PRIDE project URI
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