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PXD004998-1

PXD004998 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDetection of Five Solid Carcinomas Using Blood Circulating Proteins
DescriptionWhen diagnosed in a metastatic stage cancer is mostly incurable making its early detection via biomarkers of immense clinical interest. Proteins circulating in blood are a preferred source of biomarkers for a wide range of cancers due to the ease and non-invasiveness of collection. Our approach to cancer biomarker discovery is based on the observation that proteomic changes in tumor tissue are remotely detectable as changes in the protein composition of blood plasma. To determine whether these changes in the plasma of patients are specific for their specific cancer or represent a response to cancer in general we performed a cross-tumor plasma proteomic study. Using a proteomic serum/plasma workflow consisting of the combined use of N-glycosite enrichment and SWATH mass spectrometry (SWATH-MS), we investigated 155 blood samples derived from cohorts of patients with carcinomas at a localized or locally advanced clinical stage, or from a matched control group. A quantitative comparison of the resulting N-glycosite profiles indicated that some biomarkers are common to several cancers, while others are highly specific for one cancer type.
HostingRepositoryPRIDE
AnnounceDate2018-08-09
AnnouncementXMLSubmission_2018-08-09_08:29:45.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTatjana Sajic
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue; deamidated residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-09-20 00:16:04ID requested
12018-08-09 08:29:46announced
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biomedical
submitter keyword: Biomarker, Plasma , N-glycoprotein, SWATH-MS
Contact List
Ruedi Aebersold
contact affiliationDepartment of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, CH-8093, Switzerland ( lab head )
contact emailaebersold@imsb.biol.ethz.ch
lab head
Tatjana Sajic
contact affiliationIMSB, ETH Zurich
contact emailsajic@imsb.biol.ethz.ch
dataset submitter
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Dataset FTP location
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PRIDE project URI
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