PXD004982
PXD004982 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | PROTEIN PROFILING OF AIA RAT JOINTS IN RESPONSE TO ANTI-ARTHRITIC THERAPY |
| Description | Troxerutin (TXR), a potent antioxidant compound shows anti-inflammatory activity and possesses hepatoprotective effect. In this study, we aimed to exploit its anti-arthritic properties using adjuvant induced arthritic model. Using relative quantitative proteomics approach, we also tried to understand the mode of action of TXR at mechanistic details and its possible usage in the treatment of arthritis. Results provide a set of candidate biomarkers for responses to TXR in the arthritis and suggest new modalities of anti-arthritic activities. A number proteins were identified from the joint homogenates of the experimental rats using isobaric tag for relative and quantitative proteomics (iTRAQ) method. The detailed study and validation of these proteins involved may be useful in finding out newer treatment modalities. |
| HostingRepository | MassIVE |
| AnnounceDate | 2018-06-04 |
| AnnouncementXML | Submission_2018-06-04_19:21:09.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Debasis Sahu |
| SpeciesList | scientific name: Rattus norvegicus; common name: Norway rat; NCBI TaxID: 10116; |
| ModificationList | unknown modification: Not applicable |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2016-09-16 01:26:52 | ID requested | |
| ⏵ 1 | 2018-06-04 19:21:09 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: proteomics, iTRAQ, adjuvant induced arthritis, Troxerutin |
Contact List
| Debasis Sahu | |
|---|---|
| lab head | |
| Debasis Sahu | |
| contact affiliation | National Institute of Immunology |
| contact email | sahu.debasis@yahoo.co.in |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080172 |
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