PXD004083 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Toxoplasma gondii Methylscan |
Description | Arginine methylation is a common posttranslational modification found on nuclear and cytoplasmic proteins that has roles in transcriptional regulation, RNA metaboolism and DNA repair. The protozoan parasite Toxoplasma gondii has a complex life cycle requiring transcriptional plasticity and has unique transcriptional regulatory pathways. Arginine methylation probably plays an important part in transcriptional regulation and splicing biology in this organism. The T. gondii genome contains five putative protein arginine methyltransferases (PRMTs), of which PRMT1 is important for cell division and growth. In order to better understand the functions of the post translational modifiction monomethyl arginine (MMA) in T. gondii we performed a proteomic analysis of monomethyl arginine (MMA) proteins in wild type and PRMT1 knockout parasites using affinity purification employing anti-MMA specific antibodies followed by mass spectrometry. |
HostingRepository | PRIDE |
AnnounceDate | 2017-02-03 |
AnnouncementXML | Submission_2017-02-03_01:15:52.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD004083 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Rama Yakubu |
SpeciesList | scientific name: Toxoplasma gondii RH; NCBI TaxID: 383379; |
ModificationList | Methyl; Oxidation; Carbamidomethyl |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-05-02 02:55:41 | ID requested | |
⏵ 1 | 2017-02-03 01:15:53 | announced | |
Publication List
Yakubu RR, Silmon de Monerri NC, Nieves E, Kim K, Weiss LM, . Mol Cell Proteomics, 16(4):567-580(2017) [pubmed] |
Keyword List
submitter keyword: Toxoplasma gondii, Methylation, Post-translational Modification, Cell Cycle, Transcription Regulation, Pathogen, Parasite, Immunoaffinity, Microbiology |
Contact List
Louis M. Weiss |
contact affiliation | Albert Einstein College of Medicine |
contact email | louis.weiss@einstein.yu.edu |
lab head | |
Rama Yakubu |
contact affiliation | Albert Einstein College of Medicine |
contact email | ramarasheed.yakubu@med.einstein.yu.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/02/PXD004083 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004083
- Label: PRIDE project
- Name: Toxoplasma gondii Methylscan