PXD003666-1

PXD003666 is an original dataset announced via ProteomeXchange.

Title	TFMI-3 plasma pull-down
Description	MASP-3 is the third protease of the lectin pathway of the complement system, but its biological function has remained obscure. To elucidate its role in complement activation, we developed a specific MASP-3 inhibitor (named TFMI-3). In this work we unambiguously demonstrate that MASP-3 acts as the exclusive pro-FD activator in resting blood.
HostingRepository	PRIDE
AnnounceDate	2016-08-24
AnnouncementXML	Submission_2016-08-24_07:01:47.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD003666
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Elod Kortvely
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Carboxymethyl; Deamidated; Oxidation
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2016-02-19 06:52:45	ID requested
⏵ 1	2016-08-24 07:01:49	announced

Dob, ó J, Szak, á, cs D, Oroszl, á, n G, Kortvely E, Kiss B, Boros E, Sz, á, sz R, Z, á, vodszky P, G, á, l P, P, á, l G, MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked. Sci Rep, 6():31877(2016) [pubmed]

curator keyword: Biological

submitter keyword: MASP-3, blood, complement, lectin pathway, alternative pathway, Factor D, inhibitor, directed protein evolution

Marius Ueffing
contact affiliation	Institute for Ophthalmic Research and Medical Proteome Center Centre for Ophthalmology Eberhard Karls University, Tuebingen, Germany
contact email	marius.ueffing@uni-tuebingen.de
lab head
Elod Kortvely
contact affiliation	University of Tuebingen
contact email	eloed.koertvely@uni-tuebingen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/08/PXD003666

PRIDE project URI

• PRIDE
  1. PXD003666
     1. Label: PRIDE project
     2. Name: TFMI-3 plasma pull-down