PXD003498-1

PXD003498 is an original dataset announced via ProteomeXchange.

Title	Influenza A virus- integrated glycomics, proteomics and glycoproteomics
Description	This study describes how site-specific glycosylation of Influenza A virus changes in response to pressures from the host immune system, thereby allowing the virus to evolve and escape neutralization. We compared the glycosylation patterns of different virus strains as they evolve and correlated this information with changes in biological activity. Furthermore, modelling and molecular dynamics studies were performed to understand the basis for glycan microheterogeneity and interactions of the virions with host-immune molecules.
HostingRepository	PRIDE
AnnounceDate	2016-04-29
AnnouncementXML	Submission_2016-04-29_00:54:52.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD003498
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Kshitij Khatri
SpeciesList	scientific name: Orthomyxoviridae; NCBI TaxID: 11308; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-01-21 01:47:21	ID requested
⏵ 1	2016-04-29 00:54:53	announced

Khatri K, Klein JA, White MR, Grant OC, Leymarie N, Woods RJ, Hartshorn KL, Zaia J, Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions. Mol Cell Proteomics, 15(6):1895-912(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: LC-MS/MS, Influenza, Hemagglutinin, Glycomics, Glycoproteomics

Joseph Zaia
contact affiliation	Center for Biomedical Mass Spectrometry, Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, United States of America
contact email	jzaia@bu.edu
lab head
Kshitij Khatri
contact affiliation	Boston University
contact email	kkhatri@bu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/04/PXD003498

PRIDE project URI

• PRIDE
  1. PXD003498
     1. Label: PRIDE project
     2. Name: Influenza A virus- integrated glycomics, proteomics and glycoproteomics