PXD003404 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Labeo rohita (Rohu) plasma MALDI-TOF MS/MS |
Description | Arsenic (As) is a toxic environmental contaminant and potential human carcinogen. Chronic intake of arsenic-contaminated water leads to arsenicosis that is a major public health problem in many parts of the world, including India and Bangladesh. Thus, the early detection of arsenic toxicity will greatly benefit patients. However, the detection of arsenicosis needs to be done early before onset of severe symptoms in which case the tools used for detection have to be both sensitive and reliable. In this context, the present study investigated plasma proteome changes in arsenic-exposed Labeo rohita, with the aim of identifying biomarkers for arsenicosis. Changes in the plasma proteome were investigated using gel-based proteomics technology. Using quantitative image analysis of the 2D protein profiles, unique protein spots were identified from the plasma proteome by MALDI-TOF-TOF-MS. Unique proteins identified included Apolipoprotein-A1 (Apo-A1), α-2 macroglobulin-like protein (A2ML), and transferrin. Highly up-regulated protein spots identified in plasma from arsenic-exposed fish were liver-specific, including Apo-A1, and A2ML consistent with liver damage. It is proposed that a combination of these proteins could serve as useful biomarkers of hepatotoxicity and chronic liver disease due to arsenic exposure. |
HostingRepository | PRIDE |
AnnounceDate | 2017-05-11 |
AnnouncementXML | Submission_2017-05-11_01:02:40.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Bimal Mohanty |
SpeciesList | scientific name: Labeo rohita (Indian major carp); NCBI TaxID: 84645; |
ModificationList | iodoacetamide derivatized residue |
Instrument | AB SCIEX instrument model |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-01-04 07:34:27 | ID requested | |
⏵ 1 | 2017-05-11 01:02:41 | announced | |
Publication List
Banerjee S, Mahanty A, Mohanty S, Mazumder DG, Cash P, Mohanty BP, Identification of potential biomarkers of hepatotoxicity by plasma proteome analysis of arsenic-exposed carp Labeo rohita. J Hazard Mater, 336():71-80(2017) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Labeo rohita, Plasma, MALDI-TOF MS/MS |
Contact List
Bimal Prasanna Mohanty |
contact affiliation | ICAR- Central Inland Fisheries Research Institute, Fishery Resource and Environmental Management Division, Biochemistry Laboratory, Proteomics Unit, Barrackpore- 700120. Ph- +919230618153 |
contact email | bimalmohanty12@rediffmail.com |
lab head | |
Bimal Mohanty |
contact affiliation | ICAR-Central Inland Fisheries Research Institute, Barrackpore |
contact email | bimalmohanty12@rediffmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003404
- Label: PRIDE project
- Name: Labeo rohita (Rohu) plasma MALDI-TOF MS/MS