PXD002793 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Tumor selective proteotoxicity of verteporfin inhibits colon cancer progression independent of YAP1 |
Description | Verteporfin (VP) inhibts colon cancer growth in vivo and in cell lines by inducing high molecular weight oligomerization of proteins. The antitumor effect of VP is independent of its YAP inhibitor activity. Tumor hypoxia contributes partly to antitumor effect of VP by impairing clearance of VP-induced high molecular weight aggregates. |
HostingRepository | PRIDE |
AnnounceDate | 2015-10-14 |
AnnouncementXML | Submission_2015-10-14_05:00:15.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sadeesh Ramakrishnan |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue; phosphorylated residue |
Instrument | Orbitrap Fusion ETD |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-08-26 01:57:08 | ID requested | |
⏵ 1 | 2015-10-14 05:00:17 | announced | |
Publication List
Zhang H, Ramakrishnan SK, Triner D, Centofanti B, Maitra D, Gy, ő, rffy B, Sebolt-Leopold JS, Dame MK, Varani J, Brenner DE, Fearon ER, Omary MB, Shah YM, Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1. Sci Signal, 8(397):ra98(2015) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Human colon derived cancer cell lines |
Contact List
Yatrik M. Shah |
contact affiliation | Associate Professor Molecular and Integrative physiology University of Michigan Ann Arbor MI 48109 USA |
contact email | shahy@umich.edu |
lab head | |
Sadeesh Ramakrishnan |
contact affiliation | University of Michigan |
contact email | sadeeshivri@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/10/PXD002793 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002793
- Label: PRIDE project
- Name: Tumor selective proteotoxicity of verteporfin inhibits colon cancer progression independent of YAP1