PXD002793

PXD002793 is an original dataset announced via ProteomeXchange.

Title	Tumor selective proteotoxicity of verteporfin inhibits colon cancer progression independent of YAP1
Description	Verteporfin (VP) inhibts colon cancer growth in vivo and in cell lines by inducing high molecular weight oligomerization of proteins. The antitumor effect of VP is independent of its YAP inhibitor activity. Tumor hypoxia contributes partly to antitumor effect of VP by impairing clearance of VP-induced high molecular weight aggregates.
HostingRepository	PRIDE
AnnounceDate	2015-10-14
AnnouncementXML	Submission_2015-10-14_05:00:15.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sadeesh Ramakrishnan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; phosphorylated residue
Instrument	Orbitrap Fusion ETD

Revision	Datetime	Status	ChangeLog Entry
0	2015-08-26 01:57:08	ID requested
⏵ 1	2015-10-14 05:00:17	announced

Zhang H, Ramakrishnan SK, Triner D, Centofanti B, Maitra D, Gy, ő, rffy B, Sebolt-Leopold JS, Dame MK, Varani J, Brenner DE, Fearon ER, Omary MB, Shah YM, Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1. Sci Signal, 8(397):ra98(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: Human colon derived cancer cell lines

Yatrik M. Shah
contact affiliation	Associate Professor Molecular and Integrative physiology University of Michigan Ann Arbor MI 48109 USA
contact email	shahy@umich.edu
lab head
Sadeesh Ramakrishnan
contact affiliation	University of Michigan
contact email	sadeeshivri@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/10/PXD002793

PRIDE project URI

• PRIDE
  1. PXD002793
     1. Label: PRIDE project
     2. Name: Tumor selective proteotoxicity of verteporfin inhibits colon cancer progression independent of YAP1