PXD002462-1

PXD002462 is an original dataset announced via ProteomeXchange.

Title	Human Protein Tyrosine Phosphatase Interaction Network
Description	As the remarkable prevalence of activated protein tyrosine kinases (TKs) as oncoproteins and their mutations being identified in numerous cancers, the control of protein tyrosine phosphorylation has been considered to play a central role in ensuring the homeostasis of cellular physiology and thus, preventing tumorigenesis. Protein tyrosine phosphatases (PTPs) can contribute to this equilibrium of protein tyrosine phosphorylation and thereby antagonize the oncogenic activities of tyrosine kinases, therefore, PTPs are prominently considered to act as tumor suppressors. To achieve a comprehensive understanding of the protein-protein interaction network for this PTP family, we isolated the ~ 70 PTP-associated protein complexes from HEK293T cells and provided a systematically proteomic analysis for this tumor suppressor family.
HostingRepository	PRIDE
AnnounceDate	2016-08-17
AnnouncementXML	Submission_2016-08-17_03:07:45.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD002462
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Xu Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	L-methionine sulfoxide: 15.994915; S-carboxamidoethyl-L-cysteine: 71.037114; iodoacetamide - site C: 57.021464
Instrument	LTQ Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-07-01 06:02:25	ID requested
⏵ 1	2016-08-17 03:07:46	announced

Li X, Tran KM, Aziz KE, Sorokin AV, Chen J, Wang W, Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics, 15(9):3030-44(2016) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Human, PTP, TAP-MS, HEK293T, LC-MSMS

Junjie Chen
contact affiliation	MD Anderson Cancer Center
contact email	jchen8@mdanderson.org
lab head
Xu Li
contact affiliation	Experimental Radiation Oncology
contact email	xulimda@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/08/PXD002462

PRIDE project URI

• PRIDE
  1. PXD002462
     1. Label: PRIDE project
     2. Name: Human Protein Tyrosine Phosphatase Interaction Network