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PXD002462 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman Protein Tyrosine Phosphatase Interaction Network
DescriptionAs the remarkable prevalence of activated protein tyrosine kinases (TKs) as oncoproteins and their mutations being identified in numerous cancers, the control of protein tyrosine phosphorylation has been considered to play a central role in ensuring the homeostasis of cellular physiology and thus, preventing tumorigenesis. Protein tyrosine phosphatases (PTPs) can contribute to this equilibrium of protein tyrosine phosphorylation and thereby antagonize the oncogenic activities of tyrosine kinases, therefore, PTPs are prominently considered to act as tumor suppressors. To achieve a comprehensive understanding of the protein-protein interaction network for this PTP family, we isolated the ~ 70 PTP-associated protein complexes from HEK293T cells and provided a systematically proteomic analysis for this tumor suppressor family.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterXu Li
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListL-methionine sulfoxide: 15.994915; S-carboxamidoethyl-L-cysteine: 71.037114; iodoacetamide - site C: 57.021464
InstrumentLTQ Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-07-01 06:02:25ID requested
12016-08-17 03:07:46announced
Publication List
Li X, Tran KM, Aziz KE, Sorokin AV, Chen J, Wang W, Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics, 15(9):3030-44(2016) [pubmed]
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: Human, PTP, TAP-MS, HEK293T, LC-MSMS
Contact List
Junjie Chen
contact affiliationMD Anderson Cancer Center
contact emailjchen8@mdanderson.org
lab head
Xu Li
contact affiliationExperimental Radiation Oncology
contact emailxulimda@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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