PXD002462 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human Protein Tyrosine Phosphatase Interaction Network |
Description | As the remarkable prevalence of activated protein tyrosine kinases (TKs) as oncoproteins and their mutations being identified in numerous cancers, the control of protein tyrosine phosphorylation has been considered to play a central role in ensuring the homeostasis of cellular physiology and thus, preventing tumorigenesis. Protein tyrosine phosphatases (PTPs) can contribute to this equilibrium of protein tyrosine phosphorylation and thereby antagonize the oncogenic activities of tyrosine kinases, therefore, PTPs are prominently considered to act as tumor suppressors. To achieve a comprehensive understanding of the protein-protein interaction network for this PTP family, we isolated the ~ 70 PTP-associated protein complexes from HEK293T cells and provided a systematically proteomic analysis for this tumor suppressor family. |
HostingRepository | PRIDE |
AnnounceDate | 2016-08-17 |
AnnouncementXML | Submission_2016-08-17_03:07:45.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD002462 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Xu Li |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | L-methionine sulfoxide: 15.994915; S-carboxamidoethyl-L-cysteine: 71.037114; iodoacetamide - site C: 57.021464 |
Instrument | LTQ Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-07-01 06:02:25 | ID requested | |
⏵ 1 | 2016-08-17 03:07:46 | announced | |
Publication List
Li X, Tran KM, Aziz KE, Sorokin AV, Chen J, Wang W, Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics, 15(9):3030-44(2016) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Human, PTP, TAP-MS, HEK293T, LC-MSMS |
Contact List
Junjie Chen |
contact affiliation | MD Anderson Cancer Center |
contact email | jchen8@mdanderson.org |
lab head | |
Xu Li |
contact affiliation | Experimental Radiation Oncology |
contact email | xulimda@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/08/PXD002462 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002462
- Label: PRIDE project
- Name: Human Protein Tyrosine Phosphatase Interaction Network