PXD002192 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic identification of cysteine cathepsin substrates shed from the surface of cancer cells |
Description | Extracellular cysteine cathepsins are known to drive cancer progression, but besides degradation of extracellular matrix proteins little is known about their physiological substrates and thus the molecular mechanisms they deploy. One of the major mechanisms used by other extracellular proteases to facilitate cancer progression is proteolytic release of the extracellular domains of transmembrane proteins or ectodomain shedding. Here we show using a mass spectrometry-based approach that cathepsins L and S act as sheddases and cleave extracellular domains of CAM adhesion proteins and transmembrane receptors from the surface of cancer cells. |
HostingRepository | PRIDE |
AnnounceDate | 2015-06-23 |
AnnouncementXML | Submission_2015-06-23_04:19:42.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marko Fonovic |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue; acetate labeling reagent (N-term) (heavy form: +3amu) |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-05-18 04:08:20 | ID requested | |
⏵ 1 | 2015-06-23 04:19:44 | announced | |
Publication List
Soboti, č B, Vizovi, š, ek M, Vidmar R, Van Damme P, Gocheva V, Joyce JA, Gevaert K, Turk V, Turk B, Fonovi, ć M, Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells. Mol Cell Proteomics, 14(8):2213-28(2015) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Degradomics, proteases, cathepsins, cancer, shedding, substrates |
Contact List
Marko Fonovic |
contact affiliation | Department of Biochemistry and Molecular and Structural Biology Jozef Stefan Institute Slovenia |
contact email | marko.fonovic@ijs.si |
lab head | |
Marko Fonovic |
contact affiliation | Jozef Stefan Institute |
contact email | marko.fonovic@ijs.si |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/06/PXD002192 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002192
- Label: PRIDE project
- Name: Proteomic identification of cysteine cathepsin substrates shed from the surface of cancer cells