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PXD001792 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHigh-throughput phosphoproteomics reveals in vivo insulin signaling dynamics
DescriptionIn this project we report 133 biologically distinct mouse liver cell (Hepa 1-6 and FL83B) and mouse tissue (brain, kidney, and liver) phosphoproteomes prepared using a newly developed scalable, single-run phosphoproteomics platform, using titanium dioxide (TiO2) based phosphopeptide enrichment and performed in 96-well format. We combine this technology with in situ hepatic stimulation, to generate time-resolved maps of insulin signaling in the mouse liver.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMario Oroshi
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-02-09 01:02:32ID requested
12015-08-19 08:41:30announced
Publication List
Humphrey SJ, Azimifar SB, Mann M, High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics. Nat Biotechnol, 33(9):990-5(2015) [pubmed]
Keyword List
curator keyword: Biomedical, Biological
submitter keyword: Mouse, Liver, Kidney, Brain, Q Exactive, Phosphoproteome
Contact List
Matthias Mann
contact affiliationDept. Proteomics and Signal Transduction Max-Planck Institute of Biochemistry
contact emailmmann@biochem.mpg.de
lab head
Mario Oroshi
contact affiliationProteomics
contact emailoroshi@biochem.mpg.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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