PXD001659 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Elucidating the Linezolid response of Staphylococcus aureus USA300 (Hi3 quantification) |
Description | The translation inhibitor Linezolid is an important antibiotic of last resort against multiresistant gram-positive pathogens including MRSA. Linezolid is reported to specifically inhibit extracellular virulence factors, but the molecular cause is unknown. To elucidate the physiological response of S. aureus to Linezolid in general and the possible inhibition of virulence factors specifically we performed a holistic study. We added Linezolid to logarithmically growing S. aureus cells and analysed the Linezolid stress response with transcriptomics, quantitative proteomics and microscopy experiments. |
HostingRepository | PRIDE |
AnnounceDate | 2016-03-18 |
AnnouncementXML | Submission_2016-03-18_09:17:29.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Florian Bonn |
SpeciesList | scientific name: Staphylococcus aureus; NCBI TaxID: 1280; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-01-08 01:25:34 | ID requested | |
⏵ 1 | 2016-03-18 09:17:30 | announced | |
2 | 2016-03-22 03:09:32 | announced | Updated publication reference for PubMed record(s): 26996810. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological |
submitter keyword: Linezolid, absolute quantification, |
Contact List
Dörte Becher |
contact affiliation | Microbial Proteomics and Mass Spectrometry, Institute for Microbiology, University of Greifswald, Germany |
contact email | dbecher@uni-greifswald.de |
lab head | |
Florian Bonn |
contact affiliation | University of Greifswald |
contact email | fbonn@uni-greifswald.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD001659
- Label: PRIDE project
- Name: Elucidating the Linezolid response of Staphylococcus aureus USA300 (Hi3 quantification)