PXD001659

PXD001659 is an original dataset announced via ProteomeXchange.

Title	Elucidating the Linezolid response of Staphylococcus aureus USA300 (Hi3 quantification)
Description	The translation inhibitor Linezolid is an important antibiotic of last resort against multiresistant gram-positive pathogens including MRSA. Linezolid is reported to specifically inhibit extracellular virulence factors, but the molecular cause is unknown. To elucidate the physiological response of S. aureus to Linezolid in general and the possible inhibition of virulence factors specifically we performed a holistic study. We added Linezolid to logarithmically growing S. aureus cells and analysed the Linezolid stress response with transcriptomics, quantitative proteomics and microscopy experiments.
HostingRepository	PRIDE
AnnounceDate	2016-03-18
AnnouncementXML	Submission_2016-03-22_03:09:30.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Florian Bonn
SpeciesList	scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2015-01-08 01:25:34	ID requested
1	2016-03-18 09:17:30	announced
⏵ 2	2016-03-22 03:09:32	announced	Updated publication reference for PubMed record(s): 26996810.

Bonn F, Pan, é, -Farr, é J, Schl, ü, ter R, Schaffer M, Fuchs S, Bernhardt J, Riedel K, Otto A, V, ö, lker U, van Dijl JM, Hecker M, M, ä, der U, Becher D, Global analysis of the impact of linezolid onto virulence factor production in S. aureus USA300. Int J Med Microbiol, 306(3):131-40(2016) [pubmed]

curator keyword: Biological

submitter keyword: Linezolid, absolute quantification,

Dörte Becher
contact affiliation	Microbial Proteomics and Mass Spectrometry, Institute for Microbiology, University of Greifswald, Germany
contact email	dbecher@uni-greifswald.de
lab head
Florian Bonn
contact affiliation	University of Greifswald
contact email	fbonn@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/03/PXD001659

PRIDE project URI

• PRIDE
  1. PXD001659
     1. Label: PRIDE project
     2. Name: Elucidating the Linezolid response of Staphylococcus aureus USA300 (Hi3 quantification)