PXD001479 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The gut microbiota affects the mucus barrier |
Description | Two C57BL/6 mice colonies maintained in two rooms in the same specific pathogen free (SPF) facility were found to have different gut microbiota and a mucus phenotype specific for each colony. The thickness and growth of the colon mucus was similar in the two colonies, but one colony had mucus not penetrable to bacteria or bacterial-sized beads, similar to what occurs in free-living wild mice. On the other hand, the other colony had an inner mucus layer that was penetrable to bacteria and beads. These different properties of the mucus in the two rooms were dependent on the microbiota, as the phenotypes were transmissible by transfer of ceacal microbiota to germ-free mice. Mice with an impenetrable mucus layer had increased amounts of Erysipelotrichi, while mice with a penetrable mucus layer had higher levels of Proteobacteria and TM7 bacteria in the distal colon mucus. Thus bacteria affect mucus barrier properties in ways that can have implications for health and disease. |
HostingRepository | PRIDE |
AnnounceDate | 2015-02-09 |
AnnouncementXML | Submission_2015-02-09_11:03:05.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ana M. Rodriguez-Pineiro |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2014-11-12 02:29:20 | ID requested | |
⏵ 1 | 2015-02-09 11:03:06 | announced | |
Publication List
Jakobsson HE, Rodr, í, guez-Pi, ñ, eiro AM, Sch, ü, tte A, Ermund A, Boysen P, Bemark M, Sommer F, B, ä, ckhed F, Hansson GC, Johansson ME, The composition of the gut microbiota shapes the colon mucus barrier. EMBO Rep, 16(2):164-77(2015) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Mucus, ileum, colon, microbiota |
Contact List
Gunnar C. Hansson |
contact affiliation | Department of Medical Biochemistry and Cell Biology University of Gothenburg Sweden |
contact email | gunnar.hansson@medkem.gu.se |
lab head | |
Ana M. Rodriguez-Pineiro |
contact affiliation | Biomedicinska inst |
contact email | ana.rodriguez@medkem.gu.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/02/PXD001479 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD001479
- Label: PRIDE project
- Name: The gut microbiota affects the mucus barrier