PXD001274 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comparison of ribosomes between control and dyskerin-depleted human cells |
Description | Dyskerin is a pseudouridine synthase involved in fundamental cellular processes (including rRNA and snRNA modification and telomere stabilization), whose function is altered in X-linked dyskeratosis congenita and cancer. Dyskerin role in ribosome processing was suggested to underlie the alterations in mRNA translation described in cells lacking dyskerin function. We compared the protein contents of 5 replicates of ribosomal preparations from control or dyskerin-depleted human cells. |
HostingRepository | PRIDE |
AnnounceDate | 2015-05-07 |
AnnouncementXML | Submission_2015-05-07_11:23:28.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yohann Couté |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2014-08-28 07:43:02 | ID requested | |
⏵ 1 | 2015-05-07 11:23:29 | announced | |
Publication List
Penzo M, Rocchi L, Brugiere S, Carnicelli D, Onofrillo C, Cout, é Y, Brigotti M, Montanaro L, Human ribosomes from cells with reduced dyskerin levels are intrinsically altered in translation. FASEB J, 29(8):3472-82(2015) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: translation |
ribosomes |
dyskerin |
nanoLC-MS/MS |
label-free quantification |
Contact List
Christophe Bruley |
contact affiliation | EDyP team, Large Scale Biology Department, iRTSV CEA - Inserm - UJF Grenoble, France |
contact email | christophe.bruley@cea.fr |
lab head | |
Yohann Couté |
contact affiliation | Laboratoire d'Etude de la Dynamique des Protéomes |
contact email | yohann.coute@cea.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/05/PXD001274 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD001274
- Label: PRIDE project
- Name: Comparison of ribosomes between control and dyskerin-depleted human cells