PXD001274

PXD001274 is an original dataset announced via ProteomeXchange.

Title	Comparison of ribosomes between control and dyskerin-depleted human cells
Description	Dyskerin is a pseudouridine synthase involved in fundamental cellular processes (including rRNA and snRNA modification and telomere stabilization), whose function is altered in X-linked dyskeratosis congenita and cancer. Dyskerin role in ribosome processing was suggested to underlie the alterations in mRNA translation described in cells lacking dyskerin function. We compared the protein contents of 5 replicates of ribosomal preparations from control or dyskerin-depleted human cells.
HostingRepository	PRIDE
AnnounceDate	2015-05-07
AnnouncementXML	Submission_2015-05-07_11:23:28.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yohann Couté
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2014-08-28 07:43:02	ID requested
⏵ 1	2015-05-07 11:23:29	announced

Penzo M, Rocchi L, Brugiere S, Carnicelli D, Onofrillo C, Cout, é Y, Brigotti M, Montanaro L, Human ribosomes from cells with reduced dyskerin levels are intrinsically altered in translation. FASEB J, 29(8):3472-82(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: translation

ribosomes

dyskerin

nanoLC-MS/MS

label-free quantification

Christophe Bruley
contact affiliation	EDyP team, Large Scale Biology Department, iRTSV CEA - Inserm - UJF Grenoble, France
contact email	christophe.bruley@cea.fr
lab head
Yohann Couté
contact affiliation	Laboratoire d'Etude de la Dynamique des Protéomes
contact email	yohann.coute@cea.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/05/PXD001274

PRIDE project URI

• PRIDE
  1. PXD001274
     1. Label: PRIDE project
     2. Name: Comparison of ribosomes between control and dyskerin-depleted human cells