PXD001020 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Redox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis |
Description | In an endotoxaemic mouse model of sepsis, a tissue-based proteomics approach for biomarker discovery identified long pentraxin 3 (PTX3) as the lead candidate for inflamed myocardium. PTX3 accumulated as an octamer due to disulphide-bond formation in heart, kidney and lung ?common organ dysfunctions seen in patients with sepsis. Oligomeric moieties of PTX3 were also detectable in the circulation. The redox-state of PTX3 was quantified over the first 11 days in critically ill adult patients with sepsis. On admission day, there was no difference in the redox-state of PTX3 between survivors and non-survivors. From day 2 onwards, the conversion of octameric to monomeric PTX3 was consistently associated with a greater survival after 28 days of follow-up. For example, by day 2 post admission, octameric PTX3 was undetectable in survivors, but still constituted more than half of total PTX3 in non-survivors (P<0.001). Monomeric PTX3 was inversely associated with cardiac damage markers NT-proBNP, high sensitivity troponin I and T. In comparison to the conventional measurements of total PTX3 or NT-proBNP, the redox-sensitive oligomerization of PTX3 was more dynamic and a superior predictor of disease outcome. |
HostingRepository | PRIDE |
AnnounceDate | 2014-07-01 |
AnnouncementXML | Submission_2014-07-01_05:47:04.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD001020 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Xiaoke Yin |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2014-05-29 01:58:44 | ID requested | |
⏵ 1 | 2014-07-01 05:47:06 | announced | |
2 | 2014-07-24 05:19:32 | announced | Updated project metadata. |
Publication List
Cuello F, Shankar-Hari M, Mayr U, Yin X, Marshall M, Suna G, Willeit P, Langley SR, Jayawardhana T, Zeller T, Terblanche M, Shah AM, Mayr M, Redox state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis. Mol Cell Proteomics, 13(10):2545-57(2014) [pubmed] |
Keyword List
submitter keyword: Biomarkers |
Host-Pathogen Interaction |
Inflammatory response |
Prognostic markers |
Protein Modification |
Serum/Plasma |
Contact List
Manuel Mayr |
contact affiliation | King's British Heart Foundation Centre, King's College London, UK |
contact email | manuel.mayr@kcl.ac.uk |
lab head | |
Xiaoke Yin |
contact affiliation | Cardiovascular Division, King's College London |
contact email | xiaoke.yin@kcl.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD001020
- Label: PRIDE project
- Name: Redox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis