PXD000593 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human CDK Family |
Description | Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that play critical roles in control of cell-cycle progression, transcription and neuronal functions. To systematically investigate the regulations and functions of CDKs, we conducted a proteomic analysis of human CDK family and identified their associated protein complexes in two different cell lines using a modified SAINT (Significance Analysis of INTeractome) method. We discovered 753 HCIPs (high-confidence candidate interaction proteins) in HEK293T cells and 352 HCIPs in MCF10A cells. |
HostingRepository | PRIDE |
AnnounceDate | 2014-08-08 |
AnnouncementXML | Submission_2014-08-08_02:33:46.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD000593 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Xu Li |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide - site C: 57.021464; S-carboxamidoethyl-L-cysteine: 71.037114; L-methionine sulfoxide: 15.994915 |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2013-11-22 02:31:30 | ID requested | |
⏵ 1 | 2014-08-08 02:33:47 | announced | |
2 | 2014-10-23 02:48:52 | announced | Updated project metadata. |
Publication List
Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J, Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. Mol Cell Proteomics, 13(11):2986-3000(2014) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Human, CDK, LC-MSMS |
Contact List
Junjie Chen |
contact affiliation | Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center |
contact email | jchen8@mdanderson.org |
lab head | |
Xu Li |
contact affiliation | Experimental Radiation Oncology |
contact email | xulimda@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/08/PXD000593 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD000593
- Label: PRIDE project
- Name: Human CDK Family