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PXD000593

PXD000593 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman CDK Family
DescriptionCyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that play critical roles in control of cell-cycle progression, transcription and neuronal functions. To systematically investigate the regulations and functions of CDKs, we conducted a proteomic analysis of human CDK family and identified their associated protein complexes in two different cell lines using a modified SAINT (Significance Analysis of INTeractome) method. We discovered 753 HCIPs (high-confidence candidate interaction proteins) in HEK293T cells and 352 HCIPs in MCF10A cells.
HostingRepositoryPRIDE
AnnounceDate2014-10-23
AnnouncementXMLSubmission_2014-10-23_02:48:51.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD000593
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterXu Li
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide - site C: 57.021464; S-carboxamidoethyl-L-cysteine: 71.037114; L-methionine sulfoxide: 15.994915
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02013-11-22 02:31:30ID requested
12014-08-08 02:33:47announced
22014-10-23 02:48:52announcedUpdated project metadata.
Publication List
Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J, Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. Mol Cell Proteomics, 13(11):2986-3000(2014) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Human, CDK, LC-MSMS
Contact List
Junjie Chen
contact affiliationExperimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
contact emailjchen8@mdanderson.org
lab head
Xu Li
contact affiliationExperimental Radiation Oncology
contact emailxulimda@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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