PXD079232

PXD079232 is an original dataset announced via ProteomeXchange.

Title	Towards a proteomic plasma biomarker panel for diagnosing vasculitis remission
Description	Active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) requires intensive immunosuppressive therapy, but continued treatment after remission is achieved can cause serious harm. Reliable biomarkers to confirm remission are lacking, forcing clinicians to prolong cost-intensive and toxic therapy unnecessarily. Routine markers, such as C-reactive protein and anti-neutrophil cytoplasmic antibodies, lack sensitivity and specificity for the remission status, failing to guide treatment de-escalation safely. After adjusting for patient characteristics and clinical variables, we explored the plasma proteome to identify reliable biomarkers of disease remission in patients with AAV. We applied a two-tiered proteomics strategy combining global discovery with targeted validation to identify a protein signature of remission. The resulting 7-protein panel was successfully implemented in a targeted mass spectrometry-based assay, with diagnostic performance confirmed in an independent patient cohort. The panel consistently outperformed routine markers. Our findings suggest that this panel may serve as a starting point for developing a clinical tool to support decision-making, with the potential to reduce treatment-related burden, mitigate toxicity, and lower healthcare costs. Moreover, our confounder-controlled proteomics approach provides a scalable blueprint for biomarker discovery in complex inflammatory diseases.
HostingRepository	PRIDE
AnnounceDate	2026-06-05
AnnouncementXML	Submission_2026-06-05_04:32:58.824.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marieluise Kirchner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-03 08:25:52	ID requested
⏵ 1	2026-06-05 04:32:59	announced

Dataset with its publication pending

submitter keyword: machine learning,vasculitis, multi-biomarker panel, plasma proteomics, anti-neutrophil cytoplasmic autoantibodies

Philipp Mertins
contact affiliation	Core Unit Proteomics, Berlin Institute of Health (BIH) at Charité and MDC, Berlin, Germany
contact email	Philipp.Mertins@mdc-berlin.de
lab head
Marieluise Kirchner
contact affiliation	Proteomics Platform, BIH@Charite
contact email	marieluise.kirchner@mdc-berlin.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD079232

PRIDE project URI

• PRIDE
  1. PXD079232
     1. Label: PRIDE project
     2. Name: Towards a proteomic plasma biomarker panel for diagnosing vasculitis remission