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PXD078319
PXD078319 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | multi-omics analysis of zinc tolerance and the maintenance of high-efficiency denitrification in Klebsiella sp. WH-E under Zn²⁺ stress |
| Description | This study systematically evaluated the denitrification performance and tolerance mechanisms of the highly efficient heterotrophic nitrifying–aerobic denitrifying strain Klebsiella sp. WH-E under Zn²⁺ stress. Under 100 mg/L Zn²⁺ stress, the heterotrophic nitrification and aerobic denitrification capabilities of Klebsiella sp. WH-E resulted in an ammonia nitrogen removal rate of 95.53% and a nitrate nitrogen removal rate of 74.00%. and the nitrite nitrogen removal rate was 72.75%. The activities of the key denitrification enzymes NAR and NIR remained largely stable, and the accumulation of NO₃⁻-N and NO₂⁻-N during nitrogen transformation was limited. Multi-omics analysis revealed that Zn²⁺ stress significantly upregulated nitrogen metabolism-related genes (narG, nirB) and metal homeostasis regulatory genes (zntA, arsR, czcC), while simultaneously regulating ABC transporters and two-component systems to maintain intracellular Zn²⁺ homeostasis. The abundance of sulfur metabolism and antioxidant-related metabolit |
| HostingRepository | iProX |
| AnnounceDate | 2026-05-13 |
| AnnouncementXML | Submission_2026-05-13_20:25:08.042.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lancheng Cao |
| SpeciesList | scientific name: Klebsiella sp.; NCBI TaxID: 576; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ FT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-13 20:24:44 | ID requested | |
| ⏵ 1 | 2026-05-13 20:25:08 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Zn²⁺ stress， Klebsiella sp. WH-E，heterotrophic nitrification–aerobic denitrification (HNAD)，denitrification mechanisms，multi-omics analysis |
Contact List
| Likun Sun | |
|---|---|
| contact affiliation | Gansu Agricultural University |
| contact email | sunlk_baby@126.com |
| lab head | |
| Lancheng Cao | |
| contact affiliation | Gansu Agricultural University |
| contact email | 1766231147@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
