⮝ Full datasets listing
PXD076333
PXD076333 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Spermidine-mediated hypusination of RBBP7 suppresses histone H4 acetylation and regulates inflammatory responses |
| Description | Spermidine, a ubiquitous polyamine, activates autophagy and extends lifespan in diverse model organisms. Its levels decline with age in humans and mice, making its supplementation a promising health and longevity promoting intervention. While spermidine is known to regulate acetylation of both histone and non histone proteins through multiple pathways, its precise mechanisms remain incompletely defined. In this study, using a spermidine based chemical probe (Alk Spd), we uncovered a novel pathway through which spermidine specifically suppresses cytoplasmic histone H4 K5/K12 acetylation. We found that spermidine covalently modifies RBBP7 via hypusination, thereby disrupting its interaction with key binding partners, including HAT1 and histone H4. Specifically, hypusination at K263 of RBBP7 is critical for impairing the RBBP7–H4 association. This reduction in histone H4K5ac and H4K12ac levels leads to significant downregulation of NFKB1 expression, ultimately attenuating inflammatory responses in cells and in vivo. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-29 |
| AnnouncementXML | Submission_2026-04-01_01:53:36.654.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jianlong Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | acetylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-30 17:24:01 | ID requested | |
| ⏵ 1 | 2026-04-01 01:53:37 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Spermidine, Hypusination, Histone H4 acetylation, RBBP7, Anti-inflammation |
Contact List
| Yaoyang Zhang | |
|---|---|
| contact affiliation | Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences |
| contact email | zyy@sioc.ac.cn |
| lab head | |
| Jianlong Li | |
| contact affiliation | Interdisciplinary Research Center of Biology and Chemistry |
| contact email | lijianlong@sioc.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
