MS/MS data for profiling of Mycobacterium tuberculosis treated with Compound 1, Compound 2, Alpibectir, Compound 3 and vehicle control: 10 samples were analyzed in parallel (TMT 10-plex) to generate whole proteome profiling data. Mycobacterium tuberculosis were treated for 72h with 1µM of the respective compound: Samples 1 and 2 treated with Compound 1, samples 3 and 4 with Compound 2, samples 5 and 6 with Alpibectir, samples 7 and 8 with Compound 3 and samples 9 and 10 with DMSO (vehicle control experiments n=1 and n=2).