PXD073843

PXD073843 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics of Plasmodium falciparum infected red blood cells under Heat Stress
Description	This project investigates changes in protein phosphorylation in the malaria parasite Plasmodium falciparum in response to heat stress. During infection parasites are exposed to febrile temperatures in the human host. Heat stress is known to trigger adaptive responses but the role of protein phosphorylation in this process is not fully understood. The aim of this study is to identify phosphorylation events that change following exposure to elevated temperature. Synchronous asexual blood stage parasites were exposed to heat stress and compared with parasites maintained at normal culture temperature. Parasites were harvested after heat stress and proteins were extracted and digested into peptides. Phosphopeptides were enriched prior to analysis by liquid chromatography coupled to tandem mass spectrometry. The resulting data provide a global view of phosphorylation changes associated with heat stress in P. falciparum. This dataset enables the identification of heat responsive phosphosites and supports analysis of signalling pathways and regulatory processes that may contribute to parasite adaptation to febrile conditions.
HostingRepository	PRIDE
AnnounceDate	2026-05-14
AnnouncementXML	Submission_2026-05-13_22:50:43.797.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Jones
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Plasmodium falciparum (isolate 3D7); NCBI TaxID: NEWT:36329;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-30 07:58:18	ID requested
⏵ 1	2026-05-13 22:50:44	announced

10.7554/eLife.107860;

Jones D, Belda H, Broncel M, Fuchs G, Anaguano D, Nofal SD, Treeck M, surface proteins into the red blood cell. Elife, 14():(2026) [pubmed]

submitter keyword: Phosphoproteomics, Heat stress, Plasmodium falciparum

Moritz Treeck
contact affiliation	Group Leader, GIMM, Lisbon, Portugal
contact email	moritz.treeck@gimm.pt
lab head
David Jones
contact affiliation	The Francis Crick Institute
contact email	david.a.e.jones@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD073843

PRIDE project URI

• PRIDE
  1. PXD073843
     1. Label: PRIDE project
     2. Name: Phosphoproteomics of Plasmodium falciparum infected red blood cells under Heat Stress