PXD072766 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | An Oleuropein-based olive leaf extract enhances the muscle mitochondrial response to acute moderate – but not maximal – intensity exercise in humans |
| Description | Sprint interval exercise (SIE) induces mitochondrial adaptations in skeletal muscle, comparable to or greater than moderate-intensity continuous exercise (MICE), despite lower training volume. These effects are partly due to enhanced mitochondrial bioenergetics, including increased Ca²⁺ uptake and pyruvate dehydrogenase (PDH) activation. Oleuropein (OLE), a compound from olive leaf extract, also promotes mitochondrial Ca²⁺ uptake and PDH activation in mice. The current study tested whether OLE could enhance these adaptations in humans during MICE or SIE. In a double-blind crossover design, healthy males performed either MICE or SIE with OLE supplementation. To elucidate the acute molecular response of skeletal muscle following exercise, we performed mass spectrometry-based proteomic analysis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-13 |
| AnnouncementXML | Submission_2026-05-13_12:06:20.400.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Loïc Dayon |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-01-07 12:35:57 | ID requested | |
| ⏵ 1 | 2026-05-13 12:06:20 | announced | |
Publication List
Keyword List
| submitter keyword: Human, LC-MSMS, Exercise, Muscle |
Contact List
| Loïc Dayon |
|---|
| contact affiliation | Nestlé Research – Nestlé Institute of Food Safety & Analytical Sciences |
| contact email | loic.dayon@rd.nestle.com |
| lab head | |
| Loïc Dayon |
|---|
| contact affiliation | Nestlé Research – Nestlé Institute of Food Safety & Analytical Sciences |
| contact email | loic.dayon@rd.nestle.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD072766
- Label: PRIDE project
- Name: An Oleuropein-based olive leaf extract enhances the muscle mitochondrial response to acute moderate – but not maximal – intensity exercise in humans
