PXD072389
PXD072389 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic profiling of extracellular vesicles derived from TGF-β-treated mouse aortic endothelial cells |
| Description | Endothelial cell dysfunction plays a critical role in the pathogenesis of chronic allograft dysfunction and tissue fibrosis. Autophagy deficiency in endothelial cells has been implicated in altered extracellular vesicle (EV) cargo composition, which may contribute to pericyte-to-myofibroblast transition. In this study, we performed quantitative proteomic analysis of EVs isolated from the culture supernatant of mouse aortic endothelial cells (MAECs) treated with or without TGF-β to identify differentially expressed proteins. EVs were isolated by ultracentrifugation and characterized according to MISEV2023 guidelines. LC-MS/MS-based proteomics was performed to compare the protein profiles between control (NC) and TGF-β-treated groups. This dataset provides insights into the molecular cargo alterations in endothelial cell-derived EVs under pro-fibrotic conditions. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-24 |
| AnnouncementXML | Submission_2025-12-23_23:40:13.023.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ruoyun Tan |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-23 23:40:00 | ID requested | |
| ⏵ 1 | 2025-12-23 23:40:13 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Exosomes, Extracellular vesicles, Endothelial cells, TGF-β, Proteomics, Mouse aortic endothelial cells, Autophagy, Fibrosis, Label-free quantification |
Contact List
| Ruoyun Tan | |
|---|---|
| contact affiliation | the First Affiliated Hospital with Nanjing Medical University |
| contact email | tanruoyun@njmu.edu.cn |
| lab head | |
| Ruoyun Tan | |
| contact affiliation | the First Affiliated Hospital with Nanjing Medical University |
| contact email | tanruoyun@njmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
