PXD072375

PXD072375 is an original dataset announced via ProteomeXchange.

Title	Mechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Description	This dataset contains brain and liver multi-omics data from male SPF C57BL/6 mice exposed to etomidate or vehicle (35% propylene glycol). Mice were assigned to five groups: chronic control (vehicle, 14 days), low-dose (etomidate 3 mg/kg, 14 days), high-dose (etomidate 6 mg/kg, 14 days), acute control (single vehicle), and acute-death (single etomidate 100 mg/kg). Brain and liver tissues were collected for DIA-based quantitative proteomics (Bruker nanoElute 2 + timsTOF Pro 2, DIA-PASEF; Spectronaut v19) and PRM validation (SpectroDive), and for untargeted metabolomics (UHPLC-Q-TOF, AB SCIEX TripleTOF 5600; mzXML + XCMS).
HostingRepository	iProX
AnnounceDate	2025-12-24
AnnouncementXML	Submission_2025-12-23_18:30:45.487.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gaolin Zheng
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-23 18:30:20	ID requested
⏵ 1	2025-12-23 18:30:46	announced

Dataset with its publication pending

submitter keyword: Etomidate, Addiction, Toxic injury, Proteomics, Metabolomics

Peng Zhang
contact affiliation	Department of Forensic Medicine & Key Laboratory of Tropical Translational Medicine of Ministry of Education, College of Basic Medical Sciences, Hainan Medical University
contact email	972421821@qq.com
lab head
Gaolin Zheng
contact affiliation	Department of Forensic Medicine & Key Laboratory of Tropical Translational Medicine of Ministry of Education, College of Basic Medical Sciences, Hainan Medical University
contact email	1162091381@qq.com
dataset submitter

iProX dataset URI