PXD072374
PXD072374 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-omics data of BPD-PH mouse model |
| Description | Integrated multi-omics analysis identified 820 differentially expressed genes, 558 differentially expressed proteins, and 1,377 differential metabolites/lipids, which were mainly enriched in pathways related to inflammation and immunity, cellular signal transduction, ferroptosis, and HIF-1 signaling. TRIM21 emerged as a central molecule exhibiting significant dynamic upregulation in the early (hyperoxic) stage and downregulation in the late (hypoxic) stage of BPD-PH. Further validation in animal models, cellular experiments and clinical samples confirmed a marked elevation of TRIM21, IL-6 and IL-8 expressions in early-stage BPD-PH infants. Mechanistic study revealed that hyperoxia induced TRIM21 upregulation, enhanced NF-κB signaling activation, and promoted PASMC proliferation and migration, while TRIM21 and NF-κB activity was decreased during later disease stages. All these data demonstrate that TRIM21 orchestrated BPD-PH inflammation and vascular remodeling in a dynamic manner of early activation and late inhibition, suggesting TRIM21 as a promising molecular target and providing mechanistic insights for the precise diagnosis and treatment of BPD-PH. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-23 |
| AnnouncementXML | Submission_2025-12-23_18:24:00.460.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Siqi Hu |
| SpeciesList | scientific name: Rattus rattus; NCBI TaxID: 10117; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-23 18:23:44 | ID requested | |
| ⏵ 1 | 2025-12-23 18:24:00 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: BPD-PH, TRIM21, inflammatory cytokines |
Contact List
| Qiuping Li | |
|---|---|
| contact affiliation | the Seventh Medical Center of PLA General Hospital |
| contact email | zhjhospital@163.com |
| lab head | |
| Siqi Hu | |
| contact affiliation | the Seventh Medical Center of PLA General Hospital |
| contact email | husiqi_2000@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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