PXD072313

PXD072313 is an original dataset announced via ProteomeXchange.

Title	Organic di-selenide hydrogel microspheres for multimodal treatment of osteoarthritis.
Description	There is a general consensus that supplementation with selenoprotein elements can effectively mitigate osteoarthritis. In this study, we addressed the deficiency of selenoprotein expression in osteoarthritis patients by developing reactive oxygen species/matrix metalloproteinase 13 (ROS/MMP13) dual-responsive selenium nanoparticle hydrogel microspheres (HSPHR). We systematically elucidated the key mechanism of oxidative stress imbalance mediated by the selenoprotein thioredoxin reductase 1 (TXNRD1) in cartilage damage associated with osteoarthritis. Furthermore, we employed HSPHR to sequentially assess their therapeutic effects on cartilage, synovium, and subchondral bone, which are the primary sites implicated in osteoarthritis pathogenesis. The findings demonstrated that HSPHR effectively intervened in the key pathogenic sites of osteoarthritis by responding to the intra-articular inflammatory microenvironment, thereby achieving comprehensive treatment of osteoarthritis from its early onset to the advanced stages.
HostingRepository	PRIDE
AnnounceDate	2025-12-24
AnnouncementXML	Submission_2025-12-23_20:18:34.966.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yang Liu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-22 14:33:33	ID requested
⏵ 1	2025-12-23 20:18:35	announced

Dataset with its publication pending

submitter keyword: selenoprotein, mitochondrial function restored, dual-responsive microsphere, cartilage regeneration, TXNRD1

Yang Liu
contact affiliation	orthopedics department，The First Affiliated Hospital of Suzhou University
contact email	dctyoung50@163.com
lab head
Yang Liu
contact affiliation	The First Affiliated Hospital of Suzhou University
contact email	dctyoung50@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD072313

PRIDE project URI

• PRIDE
  1. PXD072313
     1. Label: PRIDE project
     2. Name: Organic di-selenide hydrogel microspheres for multimodal treatment of osteoarthritis.