PXD070941 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of Molecularly Targeted Therapy-Induced Immunopeptidome in Diffuse Midline Glioma (DMG) |
| Description | We used MHC-I immunopeptidomics to study how MTX-241F, a selective EGFR/PI3K inhibitor, alters antigen presentation in diffuse midline glioma (H3K27M) and glioblastoma xenografts. MHC-I–bound peptides from vehicle- and drug-treated tumors were profiled by LC–MS/MS to identify tumor- and treatment-specific peptides, including candidate brain-enriched biomarkers and immunotherapy targets. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-10 |
| AnnouncementXML | Submission_2026-02-10_06:02:47.660.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Habeebah Owolabi |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue; deamidated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-19 07:24:00 | ID requested | |
| ⏵ 1 | 2026-02-10 06:02:48 | announced | |
Publication List
| Khairkhah N, Owolabi H, Namvar A, Ibrahim MMH, Nyayapathy S, Jones R, Rumble JM, Whitehead CE, Sebolt-Leopold JS, Everest-Dass A, Galban S, Identification of molecularly targeted therapy-induced immunopeptidome in diffuse midline glioma (DMG). Neoplasia, 73():101278(2026) [pubmed] |
| 10.1016/j.neo.2026.101278; |
Keyword List
| submitter keyword: Immunopeptidomics, DMG, mass spectrometry, epigenetic remodeling, GBM |
Contact List
| Stefanie Galban |
|---|
| contact affiliation | Center for Molecular Imaging, Departments of Radiology and Surgery, The University of Michigan, BSRB A502, Ann Arbor, MI 48109, United States. |
| contact email | sgalban@umich.edu |
| lab head | |
| Habeebah Owolabi |
|---|
| contact affiliation | Griffith university |
| contact email | habeebah.owolabi@griffithuni.edu.au |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD070941 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070941
- Label: PRIDE project
- Name: Identification of Molecularly Targeted Therapy-Induced Immunopeptidome in Diffuse Midline Glioma (DMG)
