PXD070502

PXD070502 is an original dataset announced via ProteomeXchange.

Title	Multi-omics profiling of the host response to Leptospira infection in human PBMCs
Description	This study provides a comprehensive multi-omics analysis of the human host response during acute leptospirosis. We performed integrated transcriptomic and proteomic profiling of peripheral blood mononuclear cells (PBMCs) from clinically confirmed leptospirosis patients and healthy controls. Our analysis reveals widespread dysregulation of host pathways, including potent activation of TNF-alpha/NF-kappaB signaling, interferon responses, and inflammatory and immunometabolic pathways. We identified a conserved core host response signature, validated key immune mediators in an ex vivo whole-blood infection model, and pinpointed a multi-protein signature associated with the disease. This dataset offers a valuable resource for understanding the molecular mechanisms of host-pathogen interactions in leptospirosis and identifies potential biomarkers and therapeutic targets.
HostingRepository	PRIDE
AnnounceDate	2026-05-13
AnnouncementXML	Submission_2026-05-13_11:03:30.245.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Faisal Syed M
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-09 09:12:56	ID requested
⏵ 1	2026-05-13 11:03:30	announced

Dataset with its publication pending

submitter keyword: Leptospira interrogans

multi-omics

transcriptomics

proteomics

PBMC

biomarker

host immune response.

Syed M. Faisal
contact affiliation	National Institute of Animal Biotechnology, Hyderabad, India
contact email	faisal@niab.org.in
lab head
Faisal Syed M
contact affiliation	National Institute of Animal Biotechnology
contact email	faisallab.niab@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD070502

PRIDE project URI

• PRIDE
  1. PXD070502
     1. Label: PRIDE project
     2. Name: Multi-omics profiling of the host response to Leptospira infection in human PBMCs