PXD069603

PXD069603 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Profiling the stress-dependent ubiquitinome of HEK293T cells via TUBE-capture and spectral counting proteomics
Description	Here we investigate changes to the ubiquitin conjugation profile in response to various types of cellular stress. Ubiquitinated proteins from HEK293T cells following stress treatments and compared to those in unstressed cells using TUBE-affinity captured and MS-spectral counting analysis. This work is associated with the Science paper published in 2021 (Maxwell et.al. Ubiquitination is essential for recovery of cellular activities after heat shock)
HostingRepository	PRIDE
AnnounceDate	2025-10-17
AnnouncementXML	Submission_2025-10-17_14:21:17.871.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vishwajeeth Pagala
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-17 14:06:59	ID requested
⏵ 1	2025-10-17 14:21:18	announced

Publication List

10.1126/science.abc3593;
Maxwell BA, Gwon Y, Mishra A, Peng J, Nakamura H, Zhang K, Kim HJ, Taylor JP, Ubiquitination is essential for recovery of cellular activities after heat shock. Science, 372(6549):eabc3593(2021) [pubmed]

10.1126/science.abc3593;

Maxwell BA, Gwon Y, Mishra A, Peng J, Nakamura H, Zhang K, Kim HJ, Taylor JP, Ubiquitination is essential for recovery of cellular activities after heat shock. Science, 372(6549):eabc3593(2021) [pubmed]

Keyword List

submitter keyword: Ubiquitin, cellular stress, tandem ubiquitin binding entities (TUBE)

submitter keyword: Ubiquitin, cellular stress, tandem ubiquitin binding entities (TUBE)

Contact List

Paul Taylor
contact affiliation	Member Cell&Molecular Biology Department St.Jude Children's Research Hospital Memphis, TN-38105
contact email	JPaul.Taylor@STJUDE.ORG
lab head
Vishwajeeth Pagala
contact affiliation	St. Jude Children's Research Hospital
contact email	vishwajeeth.pagala@stjude.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD069603
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD069603

PRIDE project URI

Repository Record List

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