PXD068744

PXD068744 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Differential proteomics of peripheral blood CD14+ monocytes in the luminal breast carcinoma subtypes: A primary study
Description	We performed differential proteomic analysis of CD14+ monocytes from peripheral blood of BC-confirmed patients, benign individuals vs. HCs. Results revealed DEPs found across all studied cohorts such as SRSF1, CSTB, KRT2, KRT5, HEL-S-11, APOB, APOE, and ITGA2B. Herein, APOB, HEL-S-11, KRT5, and SRS1 had AUC ≥ 0.6, and are assumed as feasible classifiers of random individuals. Comparison of benign vs. HCs revealed KRT2 and KRT5, found as DAPs common for all tested groups. ENO1 found in LumA, KRT1 in LumB-HER2-, and AIDB in LumB-HER2+, were interesting BC-related DEPs analysed among top 10 hits. The GSEA analysis of LumA vs. HCs revealed enrichment of Ca2+ GNRH and LTM signalling pathways. The Ribosome and Lysosome signalling pathways were further found enriched in LumB-HER2- vs. HCs comparison and the MYC Targets V2 pathway found enriched in LumB-HER2+.
HostingRepository	PRIDE
AnnounceDate	2026-03-10
AnnouncementXML	Submission_2026-03-09_19:52:06.318.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD068744
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Miroslav Marcin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-23 09:58:38	ID requested
⏵ 1	2026-03-09 19:52:07	announced

Publication List

10.6019/PXD068744;
10.1038/s41598-026-39686-y;
Alexovi, č M, Bober P, Marcin M, Parnica J, Marcin M, Len, á, rt M, T, ó, th D, Rado, ň, ak J, Urdz, í, k P, Sabo J, monocytes in luminal breast carcinoma subtypes: in preliminary research and overview of candidate biomarker proteins. Sci Rep, 16(1):(2026) [pubmed]

10.6019/PXD068744;

10.1038/s41598-026-39686-y;

Alexovi, č M, Bober P, Marcin M, Parnica J, Marcin M, Len, á, rt M, T, ó, th D, Rado, ň, ak J, Urdz, í, k P, Sabo J, monocytes in luminal breast carcinoma subtypes: in preliminary research and overview of candidate biomarker proteins. Sci Rep, 16(1):(2026) [pubmed]

Keyword List

submitter keyword: breast cancer, LC-MSMS, B-cell lymphocytes, blood,human

submitter keyword: breast cancer, LC-MSMS, B-cell lymphocytes, blood,human

Contact List

Ján Sabo
contact affiliation	Pavol Jozef Šafárik University in Košice
contact email	jan.sabo@upjs.sk
lab head
Miroslav Marcin
contact affiliation	University of Pavol Jozef Šafárik in Košice
contact email	miroslav.marcin@upjs.sk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD068744
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD068744

PRIDE project URI

Repository Record List

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