⮝ Full datasets listing
PXD065872
PXD065872 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Intranasal administration of balenine alleviates neurodegeneration and inflammation in a mouse model of Parkinson’s disease |
| Description | Imidazole dipeptides (IDPs) have physiological properties, including antioxidant, pH-buffering, and metal ion chelating activities. Carnosine, an IDP, shows promise for treating neurodegenerative diseases, including Parkinson’s disease (PD). However, carnosine-degrading enzymes limit its bioavailability. To overcome this, we focused on balenine, a carnosine analog featuring a methylated imidazole that is resistant to degradation enzymes. In this study, we established a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride (MPTP)-induced PD mouse model and administered balenine via nasal drops to target the brain via the olfactory epithelium. The MPTP-induced PD mouse model was evaluated through various behavioral tests and biochemical analyses. Proteomic analysis was used to explore the mechanism underlying the neuroprotective effects of balenine. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-06-05 |
| AnnouncementXML | Submission_2026-06-04_16:05:49.693.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yota Tatara |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | S-carboxamidomethyl-L-cysteine; N6-acetyl-L-lysine; alpha-amino acetylated residue; 2-pyrrolidone-5-carboxylic acid (Gln); 2-pyrrolidone-5-carboxylic acid (Glu); L-methionine sulfoxide; phosphorylated L-histidine; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine |
| Instrument | TripleTOF 6600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-07 17:56:11 | ID requested | |
| ⏵ 1 | 2026-06-04 16:05:50 | announced |
Publication List
| Chukai Y, Arisumi K, Yasunaga G, Sakai H, Tatara Y, Kasai S, Yamashita T, Ishiyama E, Kiyokawa K, Ozaki T, Balenine alleviates neurodegeneration and inflammation in a mouse model of Parkinson's disease. Biochim Biophys Acta Gen Subj, 1870(7):130953(2026) [pubmed] |
Keyword List
| submitter keyword: balenine, Imidazole dipeptide, Parkinson’s disease, antioxidant |
Contact List
| Taku Ozaki | |
|---|---|
| lab head | |
| Yota Tatara | |
| contact affiliation | Hirosaki University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003923/ |
